hCG infusion before Embryo transfer

Several studies have shown that a small amount of the hormone human Chorionic Gonadotrophin (hCG) infused into the uterus shortly before embryo transfer may increase the chance of an embryo implanting.  This is an ‘Add-on’ treatment that Fertility Associates currently offers.

The chance of an embryo implanting depends on the quality of the embryo and the receptivity of the uterus. Little is known about how to influence the receptivity of the uterus, but there have been several studies looking at the infusion of a small amount of the hormone hCG before embryo transfer.

Research: A recent meta-analysis looked at the results from 15 randomised control studies that included over 2500 patients.  The conclusion was that on average infusion of hCG increased the chance of a live birth after embryo transfer.  It also appeared to lower the chance of miscarriage.

Fresh embryos: hCG infusion seemed to be more effective for the transfer of fresh embryos than frozen embryos.  An infusion within 15 minutes of embryo transfer seemed to be more effective than an infusion done earlier, and a dose of around 500iu seemed to be better than higher doses.

Overall, the evidence for a potentially beneficial effect of hCG infusion is quite high, so this is one of the Add-ons which we classify as of ‘possible benefit’. 

Click here to find out more about hCG on our Fertility Fact Sheet.